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Quality ControlQualitätskontrolle

Cell Culture Quality Control

The quality control program evaluates growth characteristics and optimal culture conditions. Major attention is focused on testing microbial contaminations caused by bacteria (notably mycoplasmas), fungi and yeasts. Additionally, all primate cell lines are screened for certain human pathogenic viruses, and positive cell lines are tested for virus production and infectivity. Results are summarized on the datasheets supplied for all cell lines in the collection.

Growth characteristics.

Cell lines are distinguished by their nutritional, growth factor, and inorganic supplement needs, as well as subculture routines, optimal cell concentrations, doubling times etc. To assist users we regularly reappraise growth parameters and update web data as necessary. More


Mycoplasma detection and eradication.

Contaminations caused by most bacteria or yeasts and fungi are usually detected quickly. Nevertheless, slow-growing bacteria, e.g. some mycoplasma and mycobacteria species frequently found in cell cultures may be chronic, detectible by sensitive assays only. More

Detection of human pathogenic viruses.

Contamination of cultured cells with human pathogenic viruses may pose health risks. Cell cultures of unknown origin or from non-approved sources should be regarded as potentially harmful until their infection status is known. The DSMZ tests all primate cell lines for the presence of various human pathogenic viruses by PCR/RT-PCR and other methods. More