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Tumor BiologyTumor Biology

Tumor Biology

The deregulation of genes due to genomic and epigenomic alterations is a common feature of tumor cells. In recent years it has become clear that in cancer cells small non-coding RNA genes are also affected by deregulation. Small non-coding RNAs comprise a heterogeneous group of RNAs which are not translated into protein. One sub-group is the microRNAs, that are 19-24 nucleotides long and negatively regulate gene expression by targeting mRNAs to degradation or inhibiting their translation. There is emerging knowledge that these small regulatory RNAs play an important role during differentiation, development and, importantly, in tumorigenesis. Furthermore, microRNAs might serve as biomarkers and targets for future therapies. But we still need a better understanding of the molecular mechanisms underlying deregulation of small non-coding RNAs and of their functional consequences in cancer to characterize the tumor suppressive or -promoting capacities of specific small RNAs.

We are investigating molecular mechanism of normal and pathologic transcriptional regulation of small non-coding RNAs in lymphoma. Aiming to clarify the functional impact of specific microRNAs for lymphomagenesis, we are analyzing their targetome and the signaling pathways these RNAs are involved in. To achieve this, we are using state-of-the-art molecular biology techniques like RNA immunoprecipitation (Figure 1) followed by next-generation sequencing and a spectrum of cell-based functional assays.

Selected References

Arribas Arranz, J, Winter, DN, Drexler, HG, Eberth, S. Suitability of Yin Yang 1 transcript and protein levels for biomarker studies in B cell non-Hodgkin lymphoma. Biomark Research. 2018; 6:11

Vlad-Fiegen A, Freytag NV, Dorn S, Müller O, Eberth S. The Wnt pathway target gene CCND1 changes mitochondrial localization and decreases mitochondrial activity in colorectal cancer cell line SW480. JBM. 2016; 4(12): 132-143. 

Drexler HG, Eberth S, Nagel S, MacLeod RA. Malignant hematopoietic cell lines: in vitro models for double-hit B-cell lymphomas. Leukemia Lymphoma. 2016; 57(5):1015-20. 

Dai H, Ehrentraut S, Nagel S, Eberth S, Pommerenke C, Dirks WG, Geffers R, Kalavalapalli S, Kaufmann M, Meyer C, Faehnrich S, Chen S, Drexler HG, MacLeod RA. Genomic Landscape of Primary Mediastinal B-Cell Lymphoma Cell Lines. PLoS One. 2015; 10(11):e0139663. 

Drexler HG, Ehrentraut S, Nagel S, Eberth S, MacLeod R: Malignant hematopoietic cell lines: In vitro models for the study of primary mediastinal B-cell lymphomas. Leukemia Research. 2015, 39(1): 18-29.

Eberth S, Schneider B, Rosenwald A, Hartmann EM, Romani J, Zaborski M, Siebert R, Drexler HG and Quentmeier H: Epigenetic regulation of CD44 in Hodgkin and non-Hodgkin lymphoma. BMC Cancer. 2010; 10:517. 

See complete list of publications:


Photo of Sonja  Eberth
Dr. Eberth, Sonja
Phone: +49-531/2616-396

Group Leader Tumor Biology

Photo of Yvonne  Merkhoffer
Merkhoffer, Yvonne
Phone: +49-531/2616-176

Technician

Photo of Julia  Romani
Romani, Julia
Phone: +49-531/2616-165

Technician

Photo of Anne-Kathrin  Schulze
Schulze, Anne-Kathrin
Phone: +49-531/2616-176

Master Student