The aim of our research is to analyze and characterize the molecular mechanisms and interactions between plant cell & virus. Plant pathogens belonging to the families of Geminiviridae and Nanoviridae cause serious crop damage worldwide. These viruses have the capacity to re-program the cell to its favors by use of multifunctional virus proteins and interaction with host factors. We want to identify these functions and interaction partners with special focus on suppression of host pathogen response and intra- and intercellular viral transport to gain basic insights into virus infection and cellular functions.
Our research focus is on
- Molecular plant virology
- Interactome analysis of plant cell and virus
- Plant viruses in biotechnology
- Mechanisms of plant virus resistance
To study the early events of virus infection in plants, avoid dilution effects and thus to obtain the most meaningful information, our group uses the MMi Cellcut microdissection system to dissect the first virus-infected plant cells during virus-plant interactions. The collected material is subsequently used in transcriptomic, proteomic and metabolomic studies at single cell resolution. Read more...
- Analyzing plant stress granules in response to plant viruses
- Development of a viral-based CRISPR/Cas-system for potato (DeviCCpo)
- Molecular and cellular aspects of the life cycle of multipartite viruses: Nanoviruses
- Multi-omics analyses of micro-dissected infected plant material
- Unravelling the nuclear manipulation by geminiviruses (GeminiNuc)