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Multi-omics analyses of micro-dissected infected plant material

It is our special emphasis to analyze the very early events of infection. Thus we identify the initial point of plant virus infection, isolate this area by microscope laser dissection and subsequently analyze this sample with a multi-omics approach.

Analyzing plant stress granules in response to plant viruses

The overall aim of this study is to analyze and to characterize the plant stress granule-component G3BP gene family in Arabidopsis thaliana and to elucidate the role of G3BP and stress granules in the general plant stress response, with special emphasis on viral infections.

This is a DFG funded project.


Molecular and cellular aspects of the life cycle of multipartite viruses: Nanoviruses

The Nanovirus project will decipher the biochemical and biological properties of various nanoviral gene products interacting with host plants. Thus, we aim to understand how distinct viral genome segments initially expressed in distinct plant cells actually function, how they can communicate and complement at a distance and at a supra-cellular scale. We will analyze the properties of the viral gene products with a focus on those with yet unknown function, and on properties that could be involved in trafficking among cells for complementation. 

This is a DFG funded project.


Unravelling the nuclear manipulation by geminiviruses (GeminiNuc)

The nucleus is the most important subcellular compartment for geminiviral invasion; spatial information regarding the subnuclear distribution of virus-related processes, however, is lacking. The aim of the project is to analyze the virus-induced cell nucleus (re)organisation, the cell nucleus interactome of geminiviruses and to identify nuclear targets of viral manipulation. Strategies aimed at impairing the viral co-option of the nucleus would potentially impact viral replication, hence providing durable resistance.

This is a DFG funded project.


Development of a viral-based CRISPR/Cas-system for potato (DeviCCpo) (project discontinued)

The DeviCCpo project will develop a novel RNA virus-based CRISPR/Cas9 delivery system, a novel application technique and, in addition, will assess a novel gene target to provide a more heat tolerant potato plant to tackle climate change challenges.