The DFG funded Transregional Collaborative Research Centre 51 (TRR 51) “Ecology, Physiology and Molecular Biology of the Roseobacter clade: Towards a Systems Biology Understanding of a Globally Important Clade of Marine Bacteria” has been established in January 2010. The DSMZ is involved with three projects. The pink members of the Roseobacter clade are among the most abundant and ecologically most significant bacteria in the oceans.
In project A5 "Evolution and significance of plasmids within the Roseobacter clade" we investigate these extrachromosomal elements which have been discovered in a remarkable wealth within these bacteria. The dynamic of the evolution of the plasmids is studied by comparative genomics. The physiological significance of specific plasmids is investigated by means of knock-out mutants which will be compared to the wild types using systems biological approaches.