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Diversity of phage-host interactions in clinical and environmental strains of bacteria of the order BurkholderialesBakteriophagen gegen Pseudomonas aeruginosa und Burkholderia cepacia: evolutionäre und anwendungsbezogene Aspekte

Diversity of phage-host interactions - characterisation of phages against pathogenic bacteria involved in cystic fibrosis

The number of multiple antibiotic resistant bacteria is dramatically increasing and there is serious concern especially in hospitals. Bacterial species like Pseudomonas aeruginosa, Staphylococcus aureus or Achromobacter xylosoxidans play a role in different states of cystic fibrosis. This research project deals with the use of bacteriophages against these infectious bacteria as a promising alternative to antibiotics. Thereby two different research lines will be followed. The first line deals with the isolation and further characterisation of new bacteriophages in order to investigate their ability to lyse multiple resistant strains of Staphylococcus aureus and Achromobacter xylosoxidans for practical use. The second line  analyses a possible role of these bacteriophages in evolution of both bacterial species as bacteriophages might act as vehicles for gene transfer by transduction.

potential therapy phage against Staphylococcus aureus ELIAVA Institute, Georgia, photo: M. Rohde
novel phage PT-JW-STHU1 (DSM 28091) against Stenotrophomonas isolated by J. Wittmann, photo: B. Henze

Project Partner at the DSMZ

Photo of Christine  Rohde
Dr. Rohde, Christine
Phone: +49-531/2616-220

All kinds of naturally occurring or genetically engineered plasmids within hosts, broad variety of phages from different habitats and for various hosts, E. coli mutants, test and host strains, medically relevant E. coli.

Photo of Johannes  Wittmann
Dr. Wittmann, Johannes
Phone: +49-531/2616-214

A broad variety of bacteriophages from different habitats and for various hosts, as well as phage genomics and phage application.