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Clostridioides difficile – metabolism and virulence

Clostridioides difficile is a major nosocomial pathogen causing severe diarrhea and pseudomembranous colitis. We employ multi-omics approaches and metabolic modelling to unravel stress responses of C. difficile, central metabolic pathways and their interconnection to virulence, both in vitro and in vivo.
Project within the consortium “CDInfect: Adaptation strategies of Clostridioides difficile during host infection”. Research in this consortium is coordinated by the TU Braunschweig (Prof. Dr. Dieter Jahn) and funded by the Federal State of Lower Saxony (Niedersächsisches Vorab)

Stress response and novel metabolic pathways in Sulfolobales

The thermoacidophilic Crenarchaea Saccharolobus (formerly Sulfolobussolfataricus and Sulfolobus acidocaldarius are model organisms for archaeal adaptation to extreme environments using broad variety of substrates. We assess both organisms with respect to novel metabolic pathways by stable isotope labelling and stress response on defined and complex substrates.
This project is in collaboration with the e:Bio initiative project “HotSysAPP”.

Adaption processes in Phaeobacter inhibens

Phaeobacter inhibens is a metabolic very versatile member of the marine Roseobacter group. We combine metabolomic and transcriptomic analyses with metabolic modelling and stable isotope labelling experiments to cover novel pathways, assign gene functions and regulation mechanisms.
This project is in collaboration with the CRC 51 “Roseobacter”.

Vesicles – implications for metabolic properties

Vesicles are frequently observed in cultivations of gram-negative bacteria, however little is known about biogenesis and metabolic properties of these vesicles and their relation to cellular metabolism.
In joint projects with colleagues from the DSMZ, the TU BS and the HZI, we try to understand basic mechanisms, composition and metabolic implications.

Development and adaptation of novel methods

In the fast progressing world of bioinformatics and analytics, we are always improving available analytical methods and implement new methods for new questions. Low molecular weight compounds are in the major focus of our analyses.
For all kinds of analysis, we are collaborating with scientists within the DSMZ and beyond.