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Clostridioides difficile – metabolism and virulence

Clostridioides difficile is a major nosocomial pathogen causing severe diarrhea and pseudomembranous colitis. We employ multi-omics approaches and metabolic modelling to unravel stress responses of C. difficile, central metabolic pathways and their interconnection to virulence, both in vitro and in vivo.
Project within the consortium “CDInfect: Adaptation strategies of Clostridioides difficile during host infection”. Research in this consortium is coordinated by the TU Braunschweig (Prof. Dr. Dieter Jahn) and funded by the Federal State of Lower Saxony (Niedersächsisches Vorab)

Stress response and novel metabolic pathways in Sulfolobales

The thermoacidophilic Crenarchaea Saccharolobus (formerly Sulfolobussolfataricus and Sulfolobus acidocaldarius are model organisms for archaeal adaptation to extreme environments using broad variety of substrates. We assess both organisms with respect to novel metabolic pathways by stable isotope labelling and stress response on defined and complex substrates.
This project is in collaboration with the e:Bio initiative project “HotSysAPP”.

Adaption processes in Phaeobacter inhibens

Phaeobacter inhibens is a metabolic very versatile member of the marine Roseobacter group. We combine metabolomic and transcriptomic analyses with metabolic modelling and stable isotope labelling experiments to cover novel pathways, assign gene functions and regulation mechanisms.
This project is in collaboration with the CRC 51 “Roseobacter”.

Vesicles – implications for metabolic properties

Vesicles are frequently observed in cultivations of gram-negative bacteria, however little is known about biogenesis and metabolic properties of these vesicles and their relation to cellular metabolism.
In joint projects with colleagues from the DSMZ, the TU BS and the HZI, we try to understand basic mechanisms, composition and metabolic implications.

Development and adaptation of novel methods

In the fast progressing world of bioinformatics and analytics, we are always improving available analytical methods and implement new methods for new questions. Low molecular weight compounds are in the major focus of our analyses.
For all kinds of analysis, we are collaborating with scientists within the DSMZ and beyond.

Aquirufa: Biodiversity and ecology of freshwater bacteria

As a partner, we join the Sparkling Science project (September 2022 to August 2025) funded by the Austrian Bundesministerium Bildung, Wissenschaft und Forschung. The genus Aquirufa is the midpoint of this citizen science project. Aquirufa is a widespread group of bacteria in freshwaters and plays an important role in the functioning of these ecosystems. The project team of the Research Department for Limnology, Mondsee (University of Innsbruck), Haus der Natur, Salzburg and the DSMZ works together with various groups of citizen scientists to study the distribution, ecology, and biodiversity of Aquirufa in freshwater habitats in Salzburg and Upper Austria. During the project six school classes, as well as additional groups of citizen scientists, will take water samples and will handle them under the instructions of the project team. We will be involved in describing newly discovered Aquirufa species scientifically. The citizen scientists will be actively involved in the whole research process, from the first beginning up to publishing. Further information can be found on www.sparklingbacteria.com.