Pathogen Repository

The Pathogen Repository is an infrastructure unit of the German Center for Infection Research (DZIF), which is located at the Leibniz Institute DSMZ. Currently, the Pathogen Repository comprises 2,398 authenticated, clinically relevant microorganisms from >150 bacterial genera. This collection of isolates is increasing continuously. Tailored to the individual needs of DZIF researchers, various deposit options have been developed (public collection, closed collection with exclusive access, security deposit and backup storage), which are free of charge. In order to support the selection of relevant strains by the depositors, a novel key strain concept has been developed, which includes relevant selection criteria (e.g. new pathogens, reference strains, strains of multicenter studies, important outbreak strains, microbiome strains). Thus, an infrastructure adapted to the needs of the DZIF TTUs was established at the Leibniz Institute DSMZ, which ensures the availability of quality-controlled, standardized and well-documented microorganisms and the associated data.
For more details on the repository please visit the Pathogen Repository collection pages

 

Selected references:

  1. Lagkouvardos I, Pukall R, Abt B, Foesel BU, Meier-Kolthoff JP, Kumar N, Bresciani A, Martínez I, Just S, Ziegler C, Brugiroux S, Garzetti D, Wenning M, Bui TP, Wang J, Hugenholtz F, Plugge CM, Peterson DA, Hornef MW, Baines JF, Smidt H, Walter J, Kristiansen K, Nielsen HB, Haller D, Overmann J, Stecher B, Clavel T. (2016) The Mouse Intestinal Bacterial Collection (miBC) provides host-specific insight into cultured diversity and functional potential of the gut microbiota. Nat Microbiol, 1:16131.
  2. Overmann J, Abt B, Sikorski J. (2017) Present and Future of Culturing Bacteria. Annu Rev Microbiol, 71:711-730.
  3. Riedel T, Neumann-Schaal M, Wittmann J, Schober I, Hofmann JD, Lu CW, Dannheim A, Zimmermann O, Lochner M, Groß U, Overmann J. (2020) Characterization of Clostridiodes difficile DSM101085 with A-B-CDT+ phenotype from a late recurrent colonization. Genome Biol Evol, accepted.