Pathogenic bacteria

PI: PD Dr. Sabine Gronow

Pathogenic bacteria are of major interest for many research projects as well as for standard applications. Not only Type strains of a large variety of species are available in this part of the collection but also rather extensive groups of strains for selected species.
Research is centered on comparative analyses to describe newly found pathogens of yet unknown species. Here, the large diversity of Type strains already present in the collection provides the background for comprehensive studies (e.g. Legionella). Furthermore, questions about the evolution of “pathogenicity“ as well as the distribution of pathogenicity factors within certain genera or families are targeted (Clostridioides difficile).
On larger collections of isolates of one species but from different sources we carry out studies such as antibiotic susceptibility tests or PCR reactions to check for specific genes (e.g. toxins, resistance factors). Isolates from clinical collections are used to perform population genomics and epidemiological studies. Especially multiresistant strains are important as targets for studies involving new potential antimicrobial substances or bacteriophages.
Additionally, the Pathogen Repository of the German Center for Infection Research (DZIF) is hosted by the DSMZ and is closely collaborating with the collection of pathogenic bacteria.

 

Selected References

  1. Hallmaier-Wacker LK, Lüert S, Gronow S, Spröer C, Overmann J, Buller N, Vaughan-Higgins RJ, Knauf S. A Metataxonomic Tool to Investigate the Diversity of Treponema. Front Microbiol. 2019;10:2094. Erratum in: Front Microbiol. 2019;10:2581.
  2. García-López M, Meier-Kolthoff JP, Tindall BJ, Gronow S, Woyke T, Kyrpides NC, Hahnke RL, Göker M. Analysis of 1,000 Type-Strain Genomes Improves Taxonomic Classification of Bacteroidetes. Front Microbiol. 2019;10:2083
  3. Oberhardt MA, Zarecki R, Gronow S, Lang E, Klenk HP, Gophna U, Ruppin E. Harnessing the landscape of microbial culture media to predict new organism-media pairings. Nat Commun. 2015;6:8493